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Acta Pharmacologica Sinica
中国药理学报 (In English) Vol.20-1999
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No.1
1.Review
High-voltage-activated calcium current and its modulation by dopamine
D4and pituitary adenylate cyclase activating polypeptide receptors in
cerebellar granule cells.
2.Original Research
Effects of superoxide anion on intracellular Ca2+ concentration in rabbit
pulmonary arterial smooth muscle cells.
Neuronal ERCC6 mRNA expression in rat brain induced by a transient focal
cerebral ischemia.
l-S.R-daurisoline protects cultured hippocampal neurons against glutamate
neurotoxicity by reducing nitric oxide production.
Effects of hyperin on free intracellular calcium in dissociated neonatal
rat brain cells.
Modulation of NMDA receptor by huperzine A in rat cerebral cortex.
Antisense oligodeoxynucleotides downregulated c-sis mRNA expression to
inhibit proliferation of vascular smooth muscle cells.
Effects of catalase and endothelin on anoxia-induced vasoconstriction
of porcine basilar artery in vitro.
Antagonistic effect of nerve growth factor on neuronal injury induced
by hypoxia in cultured cerebral cortical neurons of rats.
Drug dependence and abuse potential of tramadol.
Intestinal absorption of cefixime in rats.
Binding characteristics of pancreatic polypeptide receptors on rat hepatic
membranes.
Kanglemycin C vs ciclosporin on immunosuppression in mice.
Synergistic anticancer effects of tetrandrine combined with doxorubicin
or vincristine in vitro.
Characteristics of recombinant human butyrylcholinesterase.
Analgesic effect of agmatine and its enhancement on morphine analgesia
in mice and rats.
No.2
Expression of cardiac angiotensin-converting enzyme after myocardial infarction.
Elemene induces apoptosis and regulates expression of bcl-2 protein in
human leukemia K562 cells.
Hypoxia-ischemia altered expression of glutamate transporter EAAT1 in
neonatal rat brain.
Effects of naloxone on l-clausenamide-induced long-term potentiation in
dentate gyrus of anesthetized rats.
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated
neuroblastoma×glioma hybrid cells (NG 108-15 cells).
Effect of manoalide on apoptosis induced by deprivation of growth factors
in vascular endothelial cells.
Effect of verbascoside on decreasing concentration of oxygen free radicals
and lipid peroxidation in skeletal muscle.
Molecular modeling on kappa opioid receptor and its interaction with nonpeptide
kappa opioid agonists.
Effects of hypoxia/reoxygenation and cytokines on adhesion of leukocytes
to cerebral microvascular endothelial cells.
Inhibitory effects of huperzine B on cholinesterase activity in mice.
Neuroprotective rather than neurorescue or neurorestorative effect of
selegiline against MPTP-induced dopaminergic toxicity.
Characterization of subtype of α1-adrenoceptor mediating vasoconstriction
in perfused rat mesenteric vascular bed.
Regulatory
role of protein tyrosine phosphorylation in platelet activating factor-induced
signal transduction in platelets.
Cardioprotective effect of bradykinin-induced preconditioning mediated
by calcitonin gene-related peptide in isolated rat heart.
Effect of dexamethasone on cardiovascular response induced by norepinephrine
in nucleus tractus solitarii.
Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone
on TNF-α production in endotoxic shock.
Effect of recombinant human fibronectin polypeptide CH50 on growth and
metastasis of melanoma.
Effects of dexamethasone on intracellular Ca2+ in its sensitive cells
from neonatal mouse hippocampus and cultured cortical neurogliocytes.
Prophylactic effect of methylene blue against neurotoxicity of sodium
nitroprusside.
Effect of corticotrophin on formaldehyde-induced somatostatin of spinal
cord in rats.
No.3
Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain.
Effect of melatonin on production of hydroxyl radical and lactate dehydrogenase
during hypoxia in rat cortical slices.
Inhibitory effects of melatonin on free intracellular calcium in mouse
brain cells.
Attenuation of scopolamine-induced deficits in navigational memory performance
in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.
Population distributions of allele frequency of apolipoprotein E by age
and gender in Han Chinese.
Efflux transport of ［3H］GABA across blood-brain barrier after cerebral
ischemia-reperfusion in rats.
Effect of basic fibroblast growth factor on focal ischemic injury and
antioxidant enzyme activities.
Effects of agmatine on tolerance to and substance dependence on morphine
in mice.
Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically
infected T-lymphocytes.
Pharmacokinetics and peripheral platelet counts after a single dose of
recombinant human thrombopoietin in rhesus monkeys.
Inhibitory actions of polysaccharide sulfate on action potentials and
contraction of papillary muscles in guinea pigs.
Dual effects of tetrandrine on calcium-activated potassium channels in
pulmonary
artery smooth muscle cells.
Relationship between adenosine-induced vascular effects and ATP-sensitive
K+ channels.
Dinoprostone potentiates cytokines and lipopolysaccharides inducing nitric
oxide
production in cultured rat hepatocytes.
Securinine induced apoptosis in human leukemia HL-60 cells.
Inhibitory effects of nitric oxide and interleukin-10 on production of
tumor necrosis factor α, interleukin-1β, and interleukin-6 in mouse alveolar
macrophages.
Basic fibroblast growth factor enhanced LAK cell cytotoxicities against
human
bladder neoplasm cells.
Velvet antler polypeptides promoted proliferation of chondrocytes and
osteoblast
precursors and fracture healing.
Syntheses and biological activities of chiral piperidines-tachykinin NK3
antagonists.
No.4
Protirelin (thyrotropin-releasing hormone) in thyroid gland: possible
involvement in regulation of thyroid status.
Antagonistic effects of berbamine on ［Ca2+］i mobilization by KCl, norepinephrine,
and caffeine in newborn rat cardiomyocytes.
In vitro cytotoxicity of salvicine, a novel diterpenoid quinone.
Characterization of outward potassium current in embryonic chick heart
cells.
Involvement of NMDA and non-NMDA receptors in transmission of spinal visceral
nociception in cat.
Intraventricular vascular endothelial growth factor antibody increases
infarct volume following transient cerebral ischemia.
Effects of 7-nitroindazole on long-term potentiation induced by l-clausenamide
and high-frequency stimulation in rat hippocampus in vivo.
Inhibition by baclofen of NMDA-activated current in rat dorsal root ganglion
neurons.
Effects of excitatory amino acids and nimodipine on calcium currents in
cultured rat cortical neurons.
Nitric oxide derived from endothelial cells inhibits Na+/H+ exchange in
rabbit platelets activated by thrombin.
Effect of protopine on cytosolic Ca2+ in rabbit platelets.
Ischemic preconditioning mediated by activation of KATP channels in rat
small intestine.
Effects of simvastatin on left ventricular hypertrophy and function in
rats with aortic stenosis.
Inhibitory effects of captopril on hypoxia-induced proliferation and collagen
synthesis in pulmonary vascular smooth muscle cells.
IL-10 and trichosanthin inhibited surface molecule expression of antigen
processing cells and T-cell proliferation.
Demethylation capacity of human fetal adrenal mitochrondrial cytochrome
P-450 in vitro.
Theoretical elucidation of activity differences of five phenolic antioxidants.
Pharmacokinetics of atenolol enantiomers in 12 Chinese healthy men.
Tissue distribution of recombinant human tumor necrosis factor α derivative
in mice.
Correlation between inhibitions of morphine withdrawal and nitric-oxide
synthase by agmatine.
Dihydroetorphine-induced place preference was mediated by dopamine D1
receptors in rats.
No.5
Dynamic digital fluorescence ratio imaging of cell calcium in vascular
endothelial cells.
6,7-Dimethoxycoumarin attenuated cisplatin-induced DNA interstrand crosslink
and DNA-protein crosslink in primary cultured rabbit kidney proximal tubular
cells.
Cytosolic-Ca2+ and coxsackievirus B3-induced apoptosis in cultured cardiomyocytes
of rats.
Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured
rat luteal cell apoptosis.
Systemic anti-inflammation by synthetic interleukin-1 blockers.
Protective effect of melatonin on injuried cerebral neurons is associated
with bcl-2 protein over-expression.
Effects of calcium channel blockers on calcium release-activated calcium
currents in rat hepatocytes.
Devazepide reversed effect of sincalide against morphine on rat jejunal
activities.
Antagonistic effects of Ginkgo biloba extract on adhesion of monocytes
and neutrophils to cultured cerebral microvascular endothelial cells.
Quercetin decreased heart rate and cardiomyocyte Ca2+ oscillation frequency
in rats and prevented cardiac hypertrophy in mice.
Selective effects of alfuzosin and doxazosin with intraduodenal administration
on urethral pressure of cats.
Circumvention of tumor multidrug resistance by a new annonaceous acetogenin:
atemoyacin-B.
Gene therapy for human hepatocellular carcinoma with cytosine deaminase
gene and prodrug flucytosine.
Apoptosis and necrosis induced by sulfur mustard in Hela cells.
Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse
peritoneal macrophages induced by fibrin fibrinogen degradation products.
Effects of opioid receptor agonists on cAMP second messenger system.
Proceedings of the International Symposium on Advances of Neuroimmunology(457
No.6
Effects of ramipril on cardiac gene transcription levels of angiotensin
Ⅱ receptors after myocardial infarction
Huperzine－A in capsules and tablets for treating patients with Alzheimer
disease
Leucine－2－alanine enkephalin induced δ opioid receptors internalization
expressed stably in CHO cells
Recurrent events in meta－analysis of multiple clinical trials
Effects of low－pH treatment on cAMP second messenger system regulated
by different opioid agonists
5－HT1p receptor－mediated slow depolarization in neurons of guinea pig
inferior mesenteric ganglion
dl－3－n－Butylphthalide improves regional cerebral blood flow after experimental
subarachnoid hemorrhage in rats
Dauricine suppressed CsCl－induced early afterdepolarizations and triggered
arrhythmias in rabbit heart in vivo
Anti－arrhythmic effects of sophoridine and oxysophoridine
High glucose enhances mitogenic response to endothelin－1 in rabbit vascular
smooth muscle cells
Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine
Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia
and its relationship with platelet－activating factor
Dauricine inhibits redistribution of platelet membrane glycoprotein Ⅳ
and release of intracellular α－granule thrombospondin induced by thrombin
Flutamide suppressed prostate hypertraphy in rats and mice
Effects of antitumor compounds isolated from Pteris semipinnata L on DNA
topoisomerases and cell cycle of HL－60 cells
Suppressive effect of kanglemycin C on T－ and B－lymphocytes activation
Anti－inflammatory effects of total saponins of Panax notoginseng
Scavenging effect of chinonin on free radicals studied with quantum chemistry
Water－retention effect of suberogorgin was due to secretion of antidiuretic
hormone in rat
Effect of aerobic exercise and ginsenosides on lipid metabolism in diet－induced
hyperlipidemia mice
Effect of endothelin－1 injected into rostral ventrolateral medulla on
cardiovascular responses in cats
Action of free radical in podophyllic acid piperindyl hydrazone nitroxide
radical on its antitumor activity and toxicity
No.7
1.Review
Pharmacological regulation of striatal gene expression by metabotropic
glutamate receptors.
2.Original Research
Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
Presynaptic release of ATP from superior cervical ganglion of rats modulated
by various receptors.
Influence of agmatine in adaptation of cAMP signal transduction system
of opiate receptors.
Effects of fenfluramine combined with electroacupuncture on monoamine
release in periaqueductal gray of rat brain.
Huperzine-A capsules enhance memory and learning performance in 34 pairs
of matched adolescent students.
Effect of moxonidine on carotid sinus baroreflex in anesthetized rats.
Effects of allitridi on intracellular Ca2+ concentration in isolated rat
brain cells.
Target selectivity of MAPK phosphorothioate antisense ODN on p42/p44，p38
MAPK，and JNK protein expression and its inhibitory effect on VSMC DNA
synthesis.
Effect of advanced glycosylation end products on diacylglycerol signaling
pathway in cultured rat aortic smooth muscle cells.
Inhibitory effects of sodium quercetin monosulfate on pig platelet aggregation
induced by thrombin.
Effects of MK-447 on platelet shape change，aggregation，and ATP release
by collagen，ADP，and stable analogue of thromboxane A2 in rabbit platelets.
Inhibitory effects of estradiol on inward rectifier and delayed rectifier
K+ currents in guinea pig ventricular myocytes.
Protective effects of Ginkgo biloba extract on cultured rat cardiomyocytes
damaged by H2O2.
Hypotensive effect of tenuifolic saponin and its mechanism.
Glutathione antagonized cyclophosphamide and acroleininduced cytotoxicity
of PC3 cells and immunosuppressive actions in mice.
R-dl-Verapamil downmodulates multidrug resistance of KBv200 cells to vincristine
and doxorubicin.
Bronchodilating effects of bambuterol on bronchoconstriction in guinea
pigs.
Pharmacokinetics of 2-hydroxyflutamide，a major metabolite of flutamide，in
normal and CCl4-poisoned rats.
Effects of acetylcholine on inositol 1,4,5-triphosphate formation in cervix
uteri myometrial cells of human.
Proceedings of '98 Beijing-Hong Kong Joint Meeting on Pharmacology
No.8
1.Review
Anti-inflammatory and nitric oxide-inhibiting properties of granulocyte
colony-stimulating factor.
Vascular effects of estrogens: rapid actions, novel mecha-nisms, and potential
therapeutic implications.
2.Original Research
Comparison of effects of surfactant and inhaled nitric oxide in rabbits
with surfactant-depleted respiratory failure.
dl-3-n-Butylphthalide attenuates reperfusion-induced blood-brain barrier
damage after focal cerebral ischemia in rats.
Antagonistic effects of shikimic acid against focal cerebral ischemia
injury in rats subjected to middle cerebral artery thrombosis.
Effects of berbamine on ATP-induced ［Ca2+］i mobilization in cultured vascular
smooth muscle cells and cardio-myocytes.
Antiviral effects of rhIFN-alpha 1 against seven influenza viruses.
Supraspinal D2 receptor involved in antinociception induced by l-terahydropalmatine.
CYP2D6 phenotype determines pharmacokinetic variability of propafenone
enantiomers in 16 HAN Chinese subjects.
Subtypes of central nicotinic receptors involved in learning and memory.
Effects of tetrandrine on changes of NMDA receptor channel in cortical
neurons of rat induced by anoxia.
L-Pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced
injury.
Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive
neuron increase in rat spinal cord after formalin-induced hyperalgesia.
Effects of pentoxifylline and protein kinase C inhibitor on phorbol ester-induced
intercellular adhesion molecule-1 expression in brain microvascular endothelial
cells.
Hydrolysis of extracellular adenine nucleotides by cultured bovine endocardial
endothelial cells.
Effect of artemether on phosphorylase, lactate dehydro-genase, adenosine
triphosphatase, and glucose-phos-phate dehydro-genase of Schistosoma japonicum
harbored in mice.
Schizontocidal effects of oral artesunate on Plasmodium berghei in mice
and P knowlesi in monkeys.
Cytokines enhance nitric oxide production from human BT325 astrocytoma
cells.
Effect of recombinant human basic fibroblast growth factor on stomach
ulcers in rats and mice.
No.9
1. Review
Acupuncture: pain management coupled to immune stimulation.
Yawning: role of hypothalamic paraventricular nitric oxide.
Secretoneurin and neurogenic inflammation.
2.Original Research
Inhibitory effect of recombinant TGFα-PE40 on vascular smooth muscle cell
proliferation.
99mTc-MIBI single-photon emission-computed tomography in diagnosis of
lung cancer and mediastinal metastasis lymph nodes.
Effects of S-21007, a potent 5-HT3 partial agonist, in mouse anxiety.
Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation
in cats.
Bepridil inhibition of sodium current in rat hippocampal CA1 neurons.
Improving effects of huperzine A on abnormal lipid peroxidation and superoxide
dismutase in aged rats.
Antagonistic effects of melatonin on glutamate release and neurotoxicity
in cerebral cortex.
Evidence for μ opioid receptor on mouse spleen lymphocytes.
Effects of intra-hippocampal injection of interleukin-2 on pain threshold
and formaldehyde-induced substance P-like immunoreactivity in periaqueductal
gray and spinal cord.
Characteristics of impaired endothelium-dependent relaxation of rat aorta
after streptozotocin-induced diabetes.
Inhibition of platelet aggregation by bovine endocardial apyrase.
Effects of fluvastatin on structure and function of resistant vessels
in spontaneously hypertensive rats.
Ca2+sensitivity of contractile system and Ca2+ release from sarcoplasmic
reticulum in skinned myocardium from rats with pressure overload LV hypertrophy
and heart failure.
No.10
1.Review
Nitric oxide-dependent mechanism of anti-ischemic myo-cardial protection
induced by monophosphoryl lipid A.
2.Original Research
Endothelin-1 releases endothelium-derived endoperoxides and thromboxane
A2 in porcine coronary arteries with regenerated endothelium.
Effect of oral administration of vitamin C on human aqueous humour ascorbate
concentration.
Comparison of 12-chloroscoulerine enantiomers on animal behavior to dopamine
receptors.
Desipramine and fluoxetine antagonized 5,7-di-hydro-xytrypta-mine-induced
lesion on rat hippocampal and cortical neurons.
Inhibitory effects of 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate
(TMB-8) on intracellular Ca2+ elevated by neurotransmitters in brain cells.
Electrophysiologic effects of agmatine on pacemaker cells in sinoatrial
node of rabbits.
Inhibitory effect of dopamine on Ca2+-calmodulin-dependent protein kinase
II activity in rat hippocampal slices.
Blocking L-calcium current by l-tetrahydropalmatine in single ventricular
myocyte of guinea pigs.
Early and delayed protection by capsaicin against reperfusion injury in
rat hearts.
Inhibitory effect of ligustrazine on proliferation of rabbit vascular
smooth muscle cells after arterial injury.
Effects of perindopril, propranolol, and dihydrochlorothiazide on cardiovascular
remodelling in spontaneously hypertensive rats.
Effects of 3-n-butylphthalide on production of vasoactive substances by
cerebral and aortic endothelial cells.
Inhibitory effect of MAP kinase antisense oligonucleotide on agiotensin
Ⅱ-induced c-myc gene expression and proliferation of rat cardiac fibroblast.
Ginkgolide A, B, and huperzine A inhibit nitric oxide production from
rat C6 and human BT325 glioma cells.
Fibrinogenolytic properties of natrahagin (a proteinase from cobra venom)
and its effect on human platelet aggrega-tion.
Platelet activating factor-induced P-selectin expression in platelets
and its related signal transduction.
Pharmacokinetics of sustained-release capsule of 5-iso-sorbide mononitrate
in 20 healthy Chinese young men.
Preparation and dissolution property of ipriflavone solid dispersion.
No.11
Effects of RP58866 on transmembrane K+ currents in mammalian ventricular
myocytes.
Chlorpromazine inhibits hepatocyte apoptosis caused by withdrawal of phenobarbital
in mice.
Comet electrophoresis of blood nucleated cells in genotoxicity assessment.
Action sites of rotation and unit firing induced by l-stepholidine and
DA agonists in basal ganglia of 6-OHDA-lesioned rats.
Effects of ligustrazine, tanshinone IIA, ubiquinone, and idebenone on
mouse water maze performance.
KN-62 provides neuroprotection against glutamate-induced excitotoxicity
in neurons.
Protection of dopaminergic antagonists against anoxia-induced inhibition
of Ca2+-calmodulin dependent protein kinase II activity in rat brain.
Effect of tetrandrine on morphine dependence in isolated guinea pig ileum.
Properties of transient outward potassium current and inward rectifier
potassium current in immature human atrial myocytes.
Effects of berbamine on intracellular calcium concentration in cultured
HeLa cells.
Effects of changrolin on potassium currents in guinea pig and rabbit single
heart cells.
Effects of ascorbic acid on human hepatoma cell proliferation and redifferentiation.
Tyrosine kinase participates in α1A-adrenoceptor-mediated increase of
intracellular calcium in human embryo kidney 293 cells.
Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-［4-(2-pyridyl)-1-piperazinyl］-7-oxo-7H-pyrido［1,2,3-de］［1,4］benzoxazine-6-carboxylic
acid (YH-6) in comparison with other antibiotics in vitro.
Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.
Effects of agmatine on afterdepolarizations induced by isoproterenol in
guinea pig papillary muscles.
Quantitative design of drug compatibility by weighted modification method.
No.12
1. Review
5－HT receptors mediating external carotid vasoconstriction in vagosympathectomized
dogs.
2. Original Research
Modulation by muscarinic receptor antagonists on negative chronotropic
effects of tetrandrine.
Antagonistic effect of l－stepholidine on striatal ischemic injury in rat.
Effect of somatostatin and its antagonist on morphine analgesia in mice.
Hypoglycemia induced by insulin increases hepatic capacity to produce
glucose from gluconeogenic amino acids.
Increased response to prostaglandin H2 precedes changes in PGH synthase－1
expression in the SHR aorta.
Hyperpolarization caused by serotonin contributes to endothelium－dependent
relaxations in the porcine coronary artery.
Liquid chromatographic－mass spectrometric measurement of the endogenous
cannabinoid 2－arachidonylglycerol in the spinal cord and peripheral nervous
system.
SR141716A induces in rats a behavioral pattern opposite to that of CB1
receptor agonists.
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self
administration in rats exposed to ethanol－vapor chambers.
CB1 receptor localization in rat spinal cord and roots，dorsal root ganglion，and
peripheral nerve.
Dopaminergic system does not play a major role in the precipitated cannabinoid
withdrawal syndrome.
Dendritic glutamate－induced bursting in prefrontal pyramidal cells: role
of NMDA and non－NMDA receptors.
Intrathecal cannabinoid administration suppresses noxious stimulus－evoked
Fos protein－like immunoreactivity in rat spinal cord: comparison with
morphine.
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