No.2


MINIREVIEWS
1. JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila　 　　
2. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension　 　
3. Activation and signaling of the p38 MAP kinase pathway　 　　
4. Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein　 　　
5. Molecular mechanism of TNF signaling and beyond　 　
6. Wnt signaling in disease and in development　 　　
7. Role of c-Abl in the DNA damage stress response　 　　
8. Role of JNK activation in apoptosis: A double-edged sword　 　　
9. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress　 　　
10. HGF/SF-Met signaling in tumor progression　 　
11. Signaling mechanisms for regulation of chemotaxis　 　
12. Mechanisms of cancer metastasis to the bone　 　　
13. Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response　 　
14. Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation　 　　
15. Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between　

No.3


REVIEW
1. Viral infections and cell cycle G2/M regulation　 　
ARTICLES
2. The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain　 　　
3. Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis　 　
4. Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines　 　
5. Residues Met76 and Gln79 in HLA-G α1 domain involved in KIR2DL4 recognition　 　　
6. Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle　 　
7. Preliminary studies on differential defense responses induced during plant communication　 　　
8. Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs　 　　
9. Endostatin promotes the anabolic program of rabbit chondrocyte　 　　
10. Identification of connexin 50 and 57 mRNA in A-type horizontal cells of the rabbit retina　 　　
RAPID COMMUNICATION
11. Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy　

No.4

ARTICLE
1. The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization　 　
REVIEWS
2. 14-3-3 proteins-an update　 　
3. The role of epigenetic inactivation of 14-3-3σin human cancer　 　
4. Epigenetic alterations in gastric carcinogenesis　 　　
5. Methyl-CpG binding proteins in the nervous system　 　　
6. Epigenetic changes in virus-associated human cancers　 　　
7. The altered DNA methylation pattern and its implications in liver cancer　 　
8. Tudor and its domains: germ cell formation from a Tudor perspective　 　
9. Chromatin domain boundaries: insulators and beyond　 　　
10. GUIDELINES FOR AUTHORS

NO.5

REVIEW
1. Making a tooth: growth factors, transcription factors, and stem cells　 　　
ARTICLES
2. Isolation and characterization of the murine Nanog gene promoter　 　　
3. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de pendent upregulation　 　　
4. Identification and characterization of new plant microRNAs using EST analysis　 　　
5. Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis　 　　
6. Involvement of regulatory volume decrease in the migration of nasopharyngeal carcinoma cells　 　　
7. The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation　 　　
8. Moderate hypothermia prevents neural cell apoptosis following spinal cord ischemia in rabbits　 　　
9. Human embryonic stem cell lines derived from the Chinese population　 　　
SHORT COMMUNICATION
10. In vitro cultivation and differentiation of fetal liver stem cells from mice

NO.6

REVIEW
1. The host type Ⅰ interferon response to viral and bacterial infections　 　　
ARTICLES
2. Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1　 　　
3. Expression of TRAIL and TRAIL receptors in normal and malignant tissues　 　　
4. Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells　 　
5. Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.)　 　　
6. Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways　 　
7. Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from developing cotton fibers　 　　
8. Identification, characteristic and phylogenetic analysis of type Ⅱ DNA topoisomerase gene in